Education/Working Experience
EDUCATION:
1998.9-2001.6 The Military Academy of the People's Liberation Army,
BeiJing, China,
Ph.D., Nephrology
1990.9-1993.9 China Medical University, LiaoNing Province, China,
M.S., Medicine
1985.9-1990.6 China Medical University, LiaoNing Province, China,
M.D., Clinical Medicine
WORK EXPERIENCE:
2003.6- present Renal Division, the First Affiliated Hospital of Dalian Medical
University; LiaoNing Province, China;Professor, Chief physician
2001.6- present Renal Division, the First Affiliated Hospital of Dalian Medical
University; LiaoNing Province, China; Director
2000.6- 2003.06 Renal Division, the First Affiliated Hospital of Dalian Medical
University; LiaoNing Province, China; associate professor, associate Chief physician, Master Supervisor
1995.9- 2000.6 Renal Division, the First Affiliated Hospital of Dalian Medical
University; LiaoNing Province, China; attending doctor
1993.9-1995.6 Renal Division, the First Affiliated Hospital of Dalian Medical
University; LiaoNing Province, China; physician
Participation in the Academic Community
2015-present Director of the Key Lab of Liaoning Integrated control for chronic
kidney diseases
Director of Nephrology Society of Liaoning Medical Association
Standing committee of Renal Pharmacological specific committee
of Chinese Pharmacological Society
2013-present Director of the Center for Renal Translational Medicine of
Liaoning Province.
2012-present Standing committee of Chinese Nephrologist Association
Associate director of the Nephrology and Purification Branch of
China Medical Women’s Association
Standing committee and Deputy Secretary-General of Chinese
Society of Nephrology
2007-2012 Standing committee of Chinese Society of Blood Purification
Administration of Chinese Hospital Association
2011 Director of the Institution of Kidney Disease of Dalian Medical
University
Publication
A. Refereed Original Articles in Journals (Corresponding author &First author)
1. Nan Shen, Hongli Lin, Taihua Wu, Dapeng Wang, Weidong Wang, Hua Xie, Jianing Zhang, Zhe Feng. Inhibition of TGF-beta1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis. Kidney Int, 2013, 84(1),64-77. Corresponding author [IF:8.52]
2. Zhou M, Ma H, Lin H, Qin J. Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices. Biomaterials, 2014;35(5):1390-401. Corresponding author [IF:8.312]
3. Lin H, Chen X, Wang J, Yu Z.Inhibition of apoptosis in rat mesangial cells by tissue inhibitor of metalloproteinase-1.Kidney Int. 2002 Jul;62(1):60-69. First author [IF:5.016]
4. Lingyu Wang, Tuaner Zhang, Ming Fang, Nan Shen, Dapeng Wang, Jiaqi Teng, Hongli Lin. Podocytes protect glomerular endothelial cells from hypoxic injury via deSUMOylation of HIF-1alpha signaling. Int J Biochem Cell Biol.2014 Nov 3;58C:17-27. Corresponding author [IF:4.24]
5. Lin H, Wang D, Wu T, Dong C, Shen N, Sun Y, Sun Y, Xie H, Wang N, Shan L. Blocking core fucosylation of TGF-β1 receptors downregulates their functions and attenuates the epithelial-mesenchymal transition of renal tubular cells. Am J Physiol Renal Physiol. 2011;300(4):F1017-25. First author [IF:3.682]
6. Nan Wang, Yeqing Shao, Yan Mei, Li Zhang, Qinggang Li, Diangeng Li, Suozhu Shi, Quan Hong, Hongli Lin, Xiangmen Chen. Novel mechanism for mesenchymal stem cells in attenuating peritoneal adhesion: Accumulation in the lung and secreting TNFα-stimulating gene-6.Stem Cell Res Ther.2012, 3(6), 51. Corresponding author [IF:3.652]
7. Cai X, Sheng J, Tang C, Nandakumar V, Ye H, Ji H, Tang H, Qin Y, Guan H, Lou F, Zhang D, Sun H, Dong H, Zhang G, Liu Z, Dong Z, Guo B, Yan H, Yan C, Wang L, Su Z, Li Y, Jones L, Huang XF, Chen SY, Wu T, Lin H. Frequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing.PLoS One. 2014;9(4):e95228. doi: 10.137Corresponding author [IF:3.534]
8. Zhang J, Lin H, Yu C, Peng H, Bai R. Multiple autoimmune syndrome revealed by nephrogenic diabetes insipidus and hypokalaemic paralysis. Lupus 2013, 2, 1178–1181. Corresponding author [IF:2.481]
9. Lingyu Wang, Jingwei Zhu, Ming Fang, Tuaner Zhang, Hua Xie, Nan Wang, Nan Shen, Hui Guo, Bo Fu, Hongli Lin. Inhibition of p53 deSUMOylation Exacerbates Puromycin Aminonucleoside-Induced Apoptosis in Podocytes. Int J Mol Sci. 2014, 15, 21314-21330. Corresponding author [IF: 2.339]
10. Li N, Xie H, Li L, Wang J, Fang M, Yang N, Lin H. Effects of Honokiol on Sepsis-Induced Acute Kidney Injury in an Experimental Model of Sepsis in Rats. Inflammation, 2014; 37(4):1191-9. Corresponding author [IF:1.921]
11. Liu Y, Xie H, Lin H, Chen S, Wang W, Zhao G, Zhang X. Coexistence of Fabry Disease and Membranous Nephropathy. Iran J Kidney Dis. 2016 Jan; 10(1):48-50. Corresponding author [IF:0.98]
12. Sun Yanling, Xie Hua, Lin Hongli. Construction and identification of recombinant adenovirus carrying human TIMP-1 shRNA gene. Genetics and Molecular Research, 2014 July 14. Corresponding author [IF:0.85]
B. Refereed commentary Article in Journal
Manjeri A. Venkatachalam, Joel M. Weinberg. New wrinkles in old receptors: core
fucosylation is yet another target to inhibit TGF-β signaling. Kidney International
(2013) 84, 11–14. (IF=8.52)
Research Projects/Grants
2016-2020 Key program of National Science Foundation of China; “The
characteristic changes and the action mechanisms of core fucosylation in renal
interstitial fibrosis”. The Director.
2015-2018 Nonprofit Industry Research Project of National Health and Family
Planning Commission “The establishment of evaluation and specification of
key technology of blood purification for affecting the quality of life in uremic
patients and medical expenses”. The Director.
2013-2016 The Research Fund for the Doctoral Program of Higher Education
“The effect of core fucosylation on biological behavior of kidney pericyte by
hypoxia-reoxygenation injury”
“Outstanding academic leaders support plan”; the First Affiliated Hospital of
Dalian Medical University
Admission Plan/Requirements
1 to 2 PhD and post-doctoral students per year.
