Education/Working Experience
1995,12-1997,10 Post-Doctor, Renal cell biology Laboratory, NIDDK/NIH, USA.
1998,12-1999,6 visiting scholar, Genetic disease laboratory, NICHD/NIH, USA.
1999,7-2000,8 Post-Doctor, Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, USA.
2000,10-2004,10 Assistant Professor, Vascular Biology Institute, University of Miami School of Medicine, USA.
2004,11-2009,11 Assistant Professor, Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, USA.
2010, 4 -2013,5 Associate Professor, Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, USA.
Participation in the Academic Community
member of Chinese Physician Society
member of Renal physiology Committee, Chinese Physiological Science Society
Publication
1.Zheng F, Striker GE, Esposito C, Lupia E, Striker LJ. Strain differences rather than hyperglycemia determine the severity of glomerulosclerosis in mice. Kidney Int; 54: 1999-2007, 1998.
2.Lenz O, Zheng F, Vilar J, Doublier S, Lupia E, Schwedler S, Striker LJ, Striker GE. The inheritance of glomerulosclerosis in mice is controlled by multiple quantitative loci. Nephrol Dial Transplant;13: 3074-3078, 1998.
3.Zheng F, Kundo GC, Zhang Z, Ward J, Demayo F, Mukherjee AB. Uteroglobin is essential in preventing Immunoglobin A nephropathy in mice. Nat Med; 5: 1018-1025, 1999.
4.Lupia E, Elliot SJ, Lenz O, Zheng F, Hattori M, Striker GE, Striker LJ. IGF-1 decreases collagen degradation in diabetic NOD mesangial cells: implications for diabetic nephropathy. Diabetes;48: 1638-1644, 1999.
5.He C, Zheng F, Striker LJ, Hattori M, Vlassara H. Altered expression of Advanced glycation endproduct receptor in NOD mouse kidney: Possible role in diabetic nephropathy. Kidney Int; 58: 1931-1940, 2000.
6.Zheng F, Kundu G, Zhang Z, Mukherjee AB, Ward J, DeMayo F. Identical glomerulopathy in two different mouse models of uteroglobin deficiency. Am J Kid Dis; 35: 362-363, 2000.
7.Zheng F, Cai W, Mitsuhashi T, Vlassara H. Lysozyme increases renal AGE clearance and suppresses AGE-mediated macrophage activation. Mol Med; 7: 737-747, 2001.
8.Potier M, Karl M, Zheng F, Elliot SJ, Striker GE, Striker LJ. Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens. Am J Pathol;160: 1877-85, 2002.
9.Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H. Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab Res Rev; 18: 224-37, 2002.
10.Fornoni A, Striker LJ, Zheng F, Striker GE. Reversibility of glucose induced changes in mesangial cell extracellular matrix depends on the genetic beckground. Diabetes; 51: 499-505, 2002.
11.Zheng F, Fornoni A, Elliot SJ, Guan Y, Breyer MD, Striker LJ, Striker GE. Upregulation of type I collagen by TGF-b in mesangial cells is blocked by PPARg activation. Am J Renal Physiol; 282: F639-48, 2002.
12.Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, Zheng F, Fisher EA and Vlassara H: Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes; 51:2082-9, 2002.
13.Peppa M, He C, Hattori M, McEvoy R, Zheng F, Vlassara H. Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.Diabetes; 52: 1441-8, 2003.
14.Zheng F, Plati AR, Potier M, Schulman I, Berho M, Leclercq B, Zisman A, Striker LJ and Striker GE. Resistance to glomerulosclerosis in B6 mice disappears after menopause. A J Path. 162: 1339-48, 2003.
15.Elliot SJ, Karl M, Berho M, Potier M, Zheng F, Leclercq B, Striker GE, Striker LJ. Estrogen deficiency accelerates progression of glomerulosclerosis in susceptible mice. Am J Pathol; 162: 1441-8, 2003.
16.Zheng F, Plati AR, Banerjee A, Elliot S, Striker LJ, Striker GE. The molecular basis of age-related kidney disease. Sci Aging Knowledge Environ; Jul 23; 2003: PE20, 2003.
17.Zheng F, Cornaccia F, Schulman I, Banerjee A, Cheng QL, Potier M, Plate AR, Berho M, Elliot SJ, Li J, Fornoni A, Zang YJ, Zisman A, Striker LJ, Striker GE: Development of Albuminuria and Glomerular Lesions in Normoglycemic B6 Recipients of db/db Mice Bone Marrow: The Role of Mesangial Cell Progenitors. Diabetes; 53:2420-2427, 2004
18.Zheng F, Cheng QL, Plati AR, Ye SQ, Berho M, Banerjee A, Potier M, Jaimes EA, Guan YF, Hao CM, Striker SJ, Striker GE: The Glomerulosclerosis of Aging in Female: Contribution of the Proinflammatory Mesangial Cell Phenotype to Macrophage Infiltration. Am J Pathol, 165:1789-98, 2004
19.Sandu O, Song K, Cai W, Zheng F, Uribarri J, Vlassara H: Insulin Resistance and Type 2 Diabetes in High Fat Fed Mice. Diabetes, 54:2314-9, 2005
20.Zheng F, Plati AR, Cheng QL, Berho M, Banerjee A, Potier M, Jy WC, Koff A, Striker LJ, Striker GE: Glomerular Aging is a Multi-Stage Reversible Process Mediated by Phenotypic Changes in Progenitors. Am J Pathol, 167:355-63, 2005
21.Yang Z, Eton D, Zheng F, Livingstone AS, Yu H: Effect of Tissue Plasminogen Activator on Vascular Smooth Cells. J Vas Surg, 42:532-8, 2005
22.Liu HX, Zheng F, Cao Q, Ren B, Zhu L, Striker GE, Vlassara H: Amelioration of Oxidant Stress by the Defensin, Lysozyme. Am J Physiol Endocrinol Metab, 290:E824-32, 2006
23.Park CW, Zhang Y, Cha DY, Su DM, Hwang MT, Fan XF, Davis L, Striker G, Zheng F, Breyer M, Guan Y: PPARa Agonist Fenofibrate Improves Diabetic Nephropathy in db/db Mice. Kidney Int, 69:1511-7, 2006
24.Vigneau C, Zheng F, Polgar K, Wilson PD, Striker G: Stem cells and kidney injury. Curr Opin Nephrol Hypertens. 15(3):238-44, 2006
25.Zheng F, Zang YJ, Plati AR, Berho M, Potier M, Elliot S, Striker LJ, Striker GE: Combined ACEI and AGE inhibition decreases the progression of diabetic nephropathy. Kidney Int, 70:507-14, 2006
26.Zhao J, Huang B, Kong HJ, Li HX, Zhu C, Zheng F, Bogunovic M, Mayer B, Ozato K, Unkeless J, Xiong H:
IRF-8/ICSBP is involved in TLR signaling and contributes to the cross talk between TLR and IFN-γ Signaling pathways. J Biol Chem, 281:100073-80, 2006
27.Liu HX, Zheng F, Li Z, Uribarri J, Ren B, Tunstead JR, Striker GE, Badimon J, Vlassara H: The denfensin, Lysozyme ameliorates atherogenesis, response to actue arterial injury and systemic oxidant stress in hyperlipidemic mice. Am J Pathol, 169:303-13, 2006
28.Shangari N, Depeint F, Furrer R, Bruce WR, Popovic M, Zheng F, O'Brien PJ: A thermolyzed diet increases oxidative stress, plasma alpha-aldehydes and colonic inflammation in the rat. Chem Biol Interact. 169:100-9, 2007
29.Zheng F and Guan Y: Thiazolidinediones: A novel class of drugs for the prevention of diabetic nephropathy? Kidney Int. 72:1301-3, 2007
30.Ruan X, Zheng F, Guan Y: PPARs and the kidney in metabolic syndrome. Am J Physiol Renal Physiol. 294:1032-47, 2008
31.Ruihua Zhang, Zheng F: PPARg and Aging: One Link Through Klotho? Kidney Int. 74:702-4, 2008
32.Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H: Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan. Am J Pathol. 173:327-36, 2008
33.Guo J, Loke J, Zheng F, Hong F, Yea S, Fukata M, Tarocchi M, Abar OT, Huang H, Sninsky JJ, Friedman SL: Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses. Hepatology. 49:960-8, 2009
34.Zhao Z, Zhao C, Zhang H, Zheng F, Cai W, Vlassara H, Ma Z: Advanced Glycation End Products Inhibit Glucose-Stimulated Insulin Secretion through Nitric Oxide-Dependent Inhibition of Cytochrome c Oxidase and ATP Synthesis. Endocrinology. 150:2569-76, 2009
35.Wu J, Mei CL, Vlassara H, Striker G, Zheng F: Oxidative Stress Induced JNK Activation Contributes to Proinflammatory Phenotype of Aging Diabetic Mesangial Cells. Am J Physiol Renal Physiol, 297:F1622-31, 2009
36.Mei CL, Zheng F: Chronic inflammation potentiates kidney aging. Seminar in Nephrology. 29:555-68, 2009
37.Torregiani M, Liu H, Wu J, Zheng F, Cai W, Striker G, Vlassara H: AGER1-Transgenic Mice are Resistant to Inflammation, Oxidative Stress and Post-Injury Intimal Hyperplasia. Am J Pathol. 175:1722-34, 2009
38.Vlassara H, Uribarri J, Ferrucci L, Cai W, Torreggiani M, Post JB, Zheng F, Striker GE: Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons. Semin Nephrol. 29:594-603, 2009
39.Vlassara H, Torreggiani M, Post JB, Zheng F, Uribarri J, Striker GE: Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging. Kidney Int Suppl. 114:S3-11, 2009
40.Wu J, Zhang R, Torregiani M, Ting A, Huabao Xiong, Striker GE, Vlassara H, Zheng F: Progressive Diabetic Nephropathy in Aging Mice: An association with oxidative Stress, ER stress, and inflammation. Am J pathol, 176:2163-76, 2010
41.Huang L, Zhang R, Wu J, Chen J, Grosjean F, Satlin LH, Klein J, Sands JM, Striker GE, Tan J, Zheng F: Increased Susceptibility to Acute ER Stress Kidney Injury in Mice Lacking TNFa and its receoptor 1. Kidney Int, 79:613-23, 2011
42.Gao X, Huang L, Grosjean F, Esposito V, Wu J, Fu L, Hu H, Tan J, He C, Gray S, Jain MK, Zheng F (co-correspondence author), Mei C: Low protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: A role for KLF15. Kidney Int, 79:987-96, 2011
43.Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, Wang W, Zhang B, Cui M, Zhang H, Liang-Chen J, Qin L, Zheng F, Huang B, Xiong H: Potentiation of Th17 cytokines in aging process contributes to the development of colitis. Cell Immunol. 266:208-17, 2011
44.Yu Y, Wang Y, Zhou LN, Zheng F: ARB treatment protects against the decrease in endothelial progenitor cells in remnant kidney model. Am J Nephrol, 33:550-7, 2011
45.Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV: Reversal of diabetic nephropathy by a ketogenic diet. PLoS One. 20;6(4):e18604, 2011
46.Wu J, Guan T, Grosjean F, Xiong H, Striker GE, Zheng F: Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest, 91:1459-71, 2011
47.Chen J, Yu ZH, Huang J, Lin HK, Gao X, Zheng F: A simple automated device for children renal biopsy: Advantage in obtaining more tissue . J Clin Pathol, 64:1029-31, 2011
48.Huang QJ, Lan FH, Wang Z, Zheng F: Akt2 suppresses GAPDH mediated apoptosis via phosphorylating GAPDH at tyr157 and inhibiting its nuclear translocation. J Bio Chem, 286:42211-20, 2011
49.Lupia E, Zheng F (co-first author), Grosjean F, Tack I, Doublier S, Elliot S, Vlassara V, Striker G: Pentosan polysulfate inhibits atherosclerosis in watanabe heritable hyperlipidemic rabbits: Differential modulation of metalloproteinase 2 and 9. Lab Invest, 92:236-45, 2012
50.Mallipattu SK, Liu R, Zheng F, Narla G, Ma'ayan A, Dikman S, Jain MK, Saleem M, D'Agati V, Klotman P, Chuang PY, He JC: Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. J Bio Chem, 287:199122-35, 2012
51.Tan J, Wu W, Xu X, Liao L, Zheng F, Messinger S, Sun X, Chen J, Yang S, Cai J, Gao X, Pileggi A, Ricordi C. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA. 307:1169-77, 2012
52.Ma L, Lan F, Zheng Z, Xie F, Wang L, Liu W, Han J, Zheng F, Xie Y, Huang Q：Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion. Mol Cancer 21;11:79， 2012
53.Zhang R, Zheng ZY, Lin J, Qu L, Zheng F: The continual presence of C3d but not IgG glomerular capillary deposition in stage I idiopathic membranous nephropathy in patients receiving corticosteroid treatment. Diagnostic Pathology, 7:109， 2012
54.Lu J, Wang Q, Huang L, Dong H, Lin L, Lin N, Zheng F （Co-correspondence）, Tan J: Palmitate Causes Endoplasmic Reticulum Stress and Apoptosis in Human Mesenchymal Stem Cells: Prevention by AMPK Activator． Endocrinology，153:5275-84， 2012
55.Esposito V, Grosjean F, Tan J, Chen J, Xiong H, Striker G, Zheng F: Chop deficiency results in elevated lipopolysaccharide induced inflammation and kidney injury. Am J Physiol, 302：F440-50,2013
56.Guo J, Gao X, Lin Z, Wu W, Huang L, Dong H, Chen J, Lu J, Fu Y, Jin Wang, Ma Y, Chen X, Wu Z, Fu-qiang He, Yang S, Liao L, Zheng F, Tan J: BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause. BMC Cell Biol. 2013; 14: 18.
57.Guo J, Zou Y, Wu Z, Wu W, Xu Z, Hu H, Huang L, Dong H, Chen J, Lu J, Fu Y, Wang J, Ma Y, Chen X, He F, Yang S, Liao L, Chen J, Zheng F （Co-correspondence）, Tan J： Protective effects of mesenchymal stromal cells on adriamycin-induced minimal change nephrotic syndrome in rats and possible mechanisms. Cytotherapy 16(4):471-84，2014
58.Luo Y, Liu Y, Liu M, Wei J, Zhang Y, Hou J, Huang W, Wang T, Li X, He Y, Ding F, Yuan L, Cai J, Zheng F, Yang JY： Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice.
Biochim Biophys Acta. 1839(2):97-106，2014
59.Huang Q, Lan F, Wang X, Yu Y, Ouyang X, Zheng F, Han J, Lin Y, Xie Y, Xie F, Liu W, Yang X, Wang H, Dong L, Wang L, Tan J. IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9. Mol Cancer. 31;13:18， 2014
60.Zhang R, Lin J, Qu L, Zheng F, Zheng Z ：C3d deposition in the media of renal arterioles is a useful marker for arteriolosclerosis in IgA nephropathy.
Ann Diagn Pathol. 18(2):104-8， 2014
61.Wang X, Lin Y, Lan F, Yu Y, Ouyang X, Wang X, Huang Q, Wang L, Tan J, Zheng F：
A GG allele of 3'-side AKT1 SNP is associated with decreased AKT1 activation and better prognosis of gastric cancer. J Cancer Res Clin Oncol. 140(8):1399-411， 2014
62.Han J, Xie Y, Lan F, Yu Y, Liu W, Chen J, Zheng F, Ouyang X, Lin X, Lin Y, Huang Q, Wang L, Tan J. Additive effects of EGF and IL-1β regulate tumor cell migration and invasion in gastric adenocarcinoma via activation of ERK1/2. Int J Oncol. 45(1):291-301， 2014
63.Wang H, Geng DM, Zhang LM, Wu XY, Zheng F：Echocardiography detection of fetal ventricular aneurysm: A report of three cases. J Clin Ultrasound. 2014 Jul 28. doi: 10.1002/jcu.22211.
64.Zheng Z, Zheng F: Immune cells, inflammation and diabetic Nephropathy. J of Dia Res, In Press
65.Chen J, Chen G, Peng W, Yu G, Lin Y, Lu L, Zheng F: Continuous Venovenous Hemofiltration Decreases Mortality and Ameliorates Acute Lung Injury in Canine Model of Severe Salt Water Drowning. Emg Med, In Press
66.Chen J, Zhang Y, Li J, Yu G, Lin Y, Lu L, Zheng F: HBV associated acute glomerulonephritis. Plos One, In revision
Research Projects/Grants
2014-2017, National Natural Science Foundation of China Grant 81370460: Role of TNFa mediated signaling in the aging of glomerular capillaries and arteries.
