Education/Working Experience

2007-2008 Oxford University Post-doctoral research

Participation in the Academic Community

Oxford Stem Cell Institute

Liaoning Society for Immunology

Liaoning Society for Cell Biology and Neural Regeneration

Dalian Society for Cell Therapy Quality Control

Research Direction

Stem cell technology and neural regeneration

Thesis or Articles Published

1)     Human Adipose-derived Mesenchymal Stem Cells: A Better Cell Source for Nervous System Diseases Application. Chinese Medical Journal.2014,127(2): 1-10

2)     Effects of vitexin-2″-O-rhamnoside and vitexin-4″-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. The Journal of Pharmacy and Pharmacology, 2014, in press

3)     Rat cortex and hippocampus-derived soluble factors for the induction of adipose-derived mesenchymal stem cells into neuron-like cells. Cell Biology International, 2014 Feb 6. doi: 10.1002/cbin.10256

4)     Synthetic nucleic acids delivered by exosomes: a potential therapeutic for gene-related metabolic brain diseases. Metabolic Brain Disease. 2013, 28(4):551 - 562

5)     A novel approach to facilitate dopaminergic neuron generation from stem-cells: the combination of genetic modification and signaling factors within a three-dimensional perfusion microbioreactor. Med Hypotheses. 2013，80：407-410.

6)     Caveolin-1, through Its Ability to Negatively Regulate TLR4, is a Crucial Determinant of MAPK Activation in LPS-challenged Mammary Epithelial Cells. Asian Pacific Jorunal of Cancer Prevention. 14(2013) 2295-2299.

7)     Application of multiple parallel perfused microbioreactors: Synthesis characterization and cytoxicity testing of the novel rare earth complexes with indole acid as a ligand.Journal of Inorganic Biochemistry 128 (2013) 57–67.

8)     Exosomes: the novel vehicles for intercellular communication. Progress in Biochemistry and Biophysics. 2013, 40(8):719-727.

9)     Protective Effect of Phosphatidylcholine on Restoration of Ethanol-Injured Hepatocytes related with Caveolin-1.Journal of Membrane Biology, 2013. DOI 10.1007/s00232-013-9613-0.

10)  Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats. Neural Regeneration Research, 2013;8(29):2725-2733

11)  Electrophysiological Properties and Synaptic Function of Mesenchymal Stem Cells during Neurogenic Differentiation. The International Journal of Artificial Organs. Int J Artif Organs, 2012, 35(5): 323-37.

12)  Design of Stem Cell Therapy Facility (MS number 520). Comprehensive Biotechnology, 2011,2e (the 5Work”) edited by Murray Moo-Young , 443-454, 2011（ELSEVIER B.V.）

13)  Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats. Brain Research. 1123(2006) 68-79

14)  Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression. Metabolic Brain Disease. DOI 10.1007/s11011-014-9490-y.

15)  A New Oxovanadium Complex Enhances Renal Function by Improving Insulin Signaling Pathway in Diabetic Mice.Journal of Diabetes and Its Complications.10.1016/j.jdiacomp.2014.02.001

16)  Relationship between spatial memory in diabetic rats and protein kinase Cγ, caveolin-1 in the hippocampus and neuroprotective effect of catalpol. Chin Med J, 2014, 127(5):916-23.

Scientific Research Project

1.General Program of National Natural Science Foundation of China:Rebuild functional dopaminergic neural networks of PD model by controllable factor releasing 3 dimensional scaffold combining with target decorated AMSCs.2013-2016

2.Granted Advanced Program for Returned Overseas Researchers fromMinistry of Human Resources and Social Security: Developing the key technology for organ-specific stem cells implantation scaffold and directional growth and differentiation.2013-2015

3. Dalian Science and Technology project: Key technology research and development of human organic stem cell and tissue engineering. 2012-2014

4. General Program of National Natural Science Foundation of China: Construction of functional dopaminergic neural networks by 3D co-culture of hBMSCs/ dopaminergic neural in black substance with stratified microbial reactor irrigator. 2011-2013

5. Livelihood science and technology project of Dalian science and technology Bureau: The key technology Development for organ-specific stem cells implantation scaffold and directional growth and differentiation.2011-2013

6.Scientific Research Foundation for Returned Overseas Researchersfrom Ministry of Education: Dynamics of synapses structure during the neural differentiation of human marrow mesenchymal stem cells by 3D perfusing culture. 2010-2012

7.International cooperation project of Dalian Science and Technology Bureau:

Build up Sino-UK clinical application and technology platform of stem cells. 2010-2012

8.Ph.D. Programs foundations of LiaoningScience and Technology Agency: The optimization program screening and neural network model building of BMSC neural differentiation by 3D perfusing culture. 2010-2012

9. National Science and Technology Cooperation Program of Ministry of Science and Technology: core technology introduction and joint research with Russian of organ-specific stem cells transplantation and orientated growth and differentiation. 2010-2012

10. UK, [EPSRC]: Development of a smart bioreactor for mammalian adherent cell expansion for application to cell therapy. Cooperator, 2009-2010