Education/Working Experience
1999-2004 Bachelor Clinical Medicine Dalian Medical University, China
2004-2007 Master Biotechnology and Molecular Biology，Dalian Medical University, China
2007-2011 Ph.D Oncology University of Edinburgh, United Kingdom
2011-present Associate professor Biotechnology Dalian Medical University,China
Participation in the Academic Community
2010-present Society for Melanoma Research Member
Publication
1.Liu J, Bai J, Jiang G, Li X, Wang J, Wu D, Owusu L, Zhang E, Li W*.Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration. PLoS One. 2015;10(11):e0142157.
2.Owusu L, Wang B, Du Y, Li W*, Xin Y*. The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression. Journal of Cancer. 2015;1;6(2):128-38.
3.Chen Y, Liu ZJ, Liu J, Liu LK, Zhang ES, Li WL*. Inhibition of metastasis and invasion of ovarian cancer cells by crude polysaccharides from rosa roxburghii tratt in vitro. Asian Pac J Cancer Prev. 2014;15(23):10351-4.
4.Wan Y, Xin Y, Zhang C, Wu D, Ding D, Tang L, Owusu L, Bai J, Li W*. Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway. Oncol Lett. 2014;7(5):1738-1742.
5.Li X, Zhang C, Li W, Wu D, Liu J, Tang L, Xin Y*. In vivo effects on the intestinal microflora of Physalis alkekengi var. francheti extracts. Fitoterapia. 2013;87:43-8.
6.Weiling Li and D W Melton*. Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene, 2012, 10;31(19):2412-22.
7.Weiling Li, Liang Song and D W Melton*. Increased levels of DUSP6 phosphatase stimulate tumourigenesis in a molecularly distinct melanoma subtype. Pigment Cell Melanoma Res. 2012, 25(2):188-99.
8.Liang Song, Ann-Marie Ritchie, Ewan M. McNeil, Weiling Li, David W. Melton*. 2011, Identification of DNA repair gene Ercc1 as a novel target in melanoma. Pigment Cell Melanoma Res. 24: 5, 966–971.
Research Projects/Grants
2014-2016
Identification and functional characterization of a novel transcript variant of ERCC1
National Natural Science Foundation of China
The major goal of this study is to identify a novel transcript variant of ERCC1 and investigate its roles in chemotherapy resistance in ovarian cancer
2014-2018
The basic study of alternative end joining repair on DNA double strands break
National Natural Science Foundation of China
The goal of this study is to investigate the role of ligase I in A-EJ and the function of A-EJ in maintaining genomic stability of cells.
Admission Plan/Requirements
Admission Plan: 2 masters
