Education/Working Experience

 

2003.04-2005.08

Assistant Bioengineer, University of California, San Diego, CA, USA

2001.01-2003.03

Assistant Biomedical Researcher, University of California, Riverside, CA, USA

1996.09-2000.12

Postdoctoral Biomedical Researcher, University of California, San Diego, CA, USA

1995.09-1996.08

Postdoctoral Researcher, Indiana University, Indianapolis, IN, USA

1994.10-1995.08

Guest Scientist, Klinikum Steglitz, Free University Berlin, Germany

1989.04-1990.03

Visiting Physician, Kitasato University Hospital, Sagamihara, Japan

 

Participation in the Academic Community

 

National and International Committee:

2013-present Vice Chair, Steering Committee, Major Research Program on Vascular Homeostasis,

National Science Foundation (NSF), China

2010-present Member, Advisory Board, NSF, Department of Medicine, China

2010-present Member, Study Sections, NSF, China

2010-present Member, Sino-Korean Joint Committee on Basic Science

2010-present Member, Sino-German Reviewing Board for the Nobel Laureate Meetings at Lindau

Professional Society Membership:

2010-present Secretary General, Asian Society for Vascular Biology

2003-present Member and Vice Chair, Academic Committee, Chinese Association for Physiological

Sciences

2008-present Member and Vice Chair, Committee for Receptor Research, Chinese Association for

Pathophysiology

2010-presnt Member, Committee for Lipids and Lipoproteins, Chinese Society for Biochemistry and

Molecular Biology

1998- Member (non-continuous), American Heart Association, American Diabetes Association,

American Society of Biochemistry and Molecular Biology, American Physiology Society,

American Association for Science Advancement

 

 

Publication

 

1. Mao G, Liu Y, Fang X, Liu Y, Fang L, Lin L, Liu X,Wang N. Tumor-derived MicroRNA-494 PromotesAngiogenesis in Non-small-cell Lung Cancer.  Angiogenesis. 2015; accepted

2. FangX, FangL, LiuA, Wang X, ZhaoB, Wang N. Activation of PPAR-dInduces MicroRNA-100 and Decreases the Uptake of Very Low-Density Lipoprotein in Endothelial Cells.Br J Pharmacol. 2015; accepted

3. Liu W, Li J, Liu M, Zhang H,Wang N. PPAR-γ promotes endothelial cell migration by inducing the expression of SEMA3G.J Cell Biochem. 2015;116:514-23

4. Luo X, XiaoL, Yang H, Zhang R, Jiang M, Ni J,Wang N. HomocysteineDownregulates Gene Expression of Heme Oxygenase-1 in Hepatocytes.NutrMetab(Lond). 2014 Dec 8;11(1):55. doi: 10.1186/1743-7075-11-55.

5. Liu J, Wang L, Tian X, Liu L, Wong W, Zhang Y, Han Q, Ho H,Wang N, Wong S, Chen Z, Yu J, Ng C, Yao X, Huang Y. Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice.Diabetes. 2014; Dec 4. pii: DB_141391. [Epub ahead of print]

6. Wang X, Cheang WS, Yang H, Xiao L, Lai B, Zhang M, Ni J, Luo Z, Huang Y,Wang N.Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms.Br J Pharmacol. 2014; Nov 19. doi: 10.1111/bph.13021[Epub ahead of print]

7. Zhao L, Wang Y, Yang Y, Guo R,Wang N, Deng XL.Metformin Restores Intermediate-Conductance Calcium-Activated K+ channel- and Small-Conductance Calcium-Activated K+ channel-Mediated Vasodilatation Impaired by Advanced Glycation End Products in Rat Mesenteric Artery.MolPharmacol. 2014;86:580-91

8. Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J,Wang N. Procyanidin B2 Inhibits NLRP3 Inflammasome Activation in Human Vascular Endothelial Cells.BiochemPharmacol. 2014; 92:599-606

9. Wang S, Lei T, Zhang K, Zhao W, Fang L, Lai B, Han J, Xiao L,Wang N. Xenobiotic receptor PXR regulates innate immunity via activation of NLRP3 inflammasome in vascularendothelial cells.J Biol Chem. 2014; 289:30075-81

10. Huang Y, Zhao B, Liu Y andWang N. Peroxisome proliferator-activated receptor-g regulates the expression of lipid phosphate phosphohydrolase 1 in vascular endothelial cells.PPAR Res.2014; In press

11. Liu Y, Tian X, Huang Y andWang N. Rosiglitazone Attenuated Endothelin-1-inducedVasoconstriction of Pulmonary Arteries in the Rat Model ofPulmonary Arterial Hypertension via Differential Regulation ofET-1 Receptors.PPAR Res. 2014; Article 374075

12. Wang L, Gao S, Xu W, Zhao S, Zhou J,Wang N, Yuan Z. Allergic asthma accelerates atherosclerosis dependent on Th2 and Th17 in apolipoprotein E deficient mice.J Mol Cell Cardiol. 2014;72:20-7

13. Cheang WS, Tian XY, Wong WT, Lau CW, Lee SS, Chen ZY, Yao X,Wang N, Huang Y.Metformin Protects Endothelial Function in Diet-Induced Obese Mice by Inhibition of Endoplasmic Reticulum Stress Through 5' Adenosine Monophosphate-Activated Protein Kinase-Peroxisome Proliferator-Activated Receptor δ Pathway.ArteriosclerThrombVasc Biol. 2014;34:830-6

14. Xiao L, Liu Y,Wang N.New Paradigms of the Inflammatory Signaling in Endothelial Cells.  Am J Physiol-Heart Circ. 2014;306:H317-25

15. Zhang Y, LiuJ ,Tian X, Wong W, Chen Y, Wang Y, LuoJ, Cheang W, Lau C, Kwan K,Wang N, Yao X, Huang Y. Inhibition of bone morphogenic protein-4 restores endothelial function indb/db diabetic mice.Arterioscler Thromb Vasc Biol.2014;34:152-9.

16. Liu Y, Yan X, Mao G, Fang L, Zhao B, Liu Y, Tang H,Wang N. Metabonomic Profiling Revealed an Alteration in Purine Nucleotide Metabolism Associated with Cardiac Hypertrophy in Rats Treated with Thiazolidinediones.  J Proteomic Res. 2013; 12:5634-41.

17. Liu Y, Zhao B, Mao G, Fang X, Liu Y, Huang Y,Wang N.Epigallocatechin-3-O-Gallate, a Green Tea Polyphenol, Induces Expression of Pim-1 Kinase via PPARγ in Human Vascular Endothelial Cells.CardiovascToxicol.2013;13:391-5.

18. Zhao L, Wang Y, Ma X,Wang N, Deng X.Advanced glycation end products impair KCa3.1- and K Ca2.3-mediated vasodilatation via oxidative stress in rat mesenteric arteries.Pflugers Arch.2014; 466:307-17. 

19. Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S,Wang N.Shear stress activation of nuclear receptor PXR in endothelial detoxification.Proc Natl Acad Sci USA. 2013;110:13174-9.

20. Wang Y, Zhang Y, Qian H, Lu J, Zhang Z, Min X, Lang M, Yang H,Wang N, Zhang P.The g0/g1 switch gene 2 is an important regulator of hepatic triglyceride metabolism.PLoS One. 2013;8:e72315.

21. Zhang Y, Wang Y, Liu Y, Wang N, Qi Y, Du J. Kruppel-Like Factor 4 Transcriptionally Regulates TGF-beta1 and Contributes to Cardiac Myofibroblast Differentiation.PLoS One, 2013, 8:e63424.

22. Wang X, Liu W, Wu Y, Liu X, Liang X, Wan Z, Wang N, Yuan Z. C-reactive protein reduces protein S-nitrosylation in endothelial cells. Mol Cell Biochem, 2013, 375: 131-138.

23. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, Huang Y,Wang N. Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.Hypertension. 2012 60(6):1471-8.

24. Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian X, Yang G, Pu D, Zhang X, Kang J, Gao Y, Wang S, Breyer MD,Wang N, Zhu Y, Huang Y, Breyer RM, Guan Y. Inactivation of the E-Prostanoid 3 receptor attenuates the angiotensin II pressorresponse via decreasing arterial contractility.Arterioscler Thromb Vasc Biol.2012;32:3024-32.

25. Tian XY, Wong WT,Wang N*, Lu Y, San Cheang W, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y. PPARδ activation protects endothelial function in diabetic mice.Diabetes. 2012; 61:3285-93. [*co-corresponding author]

26. Li X, Song Y, Wang D, Fu C, Zhu Z, Han Y, Li C,Wang N, Zhu Y. LIF maintains progenitor phenotype of endothelial progenitor cells via Krüppel-like factor 4.Microvasc Res. 2012;84:270-7

27. Xu G, Wang Z, Li Y, Li Z, Tang H, Zhao J, Xiang X, Ding L, Ma L, Yuan F, Fei J, Wang W,Wang N, Guan Y, Tang C, Mulholland M, Zhang W.Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice.Diabetologia. 2012;55:1813-23

28. Wang Y, Zhao B, Zhang Y, Tang Z, Shen Q, Zhang Y, Zhang W, Du J, Chien S,Wang N. Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury.Br J Pharmacol. 2012;165:2378-2388

29. Wang N, Yin R, Liu Y, Mao G, Xi F.Role of peroxisome proliferator-activated receptor-γ in atherosclerosis: an update.Circ J. 2011;75:528-35.

30. Li J, Chi Y, Wang C, Wu J, Yang H, Zhang D, Zhu Y,Wang N, Yang J, Guan Y. Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the forkhead box 1 signaling pathway.Hepatology.2011;53:1906-16.

31. Zhu S, Xue R, Zhao P, Fan FL, Kong X, Zheng S, Han Q, Zhu Y,Wang N, Yang J, Guan Y. Targeted disruption of the prostaglandin E2 E-prostanoid 2 receptor exacerbates vascular neointimal formation in mice.Arterioscler Thromb Vasc Biol.2011;31:1739-47

32. Qin X,Wang X, Wang Y,Cui Q, Xi J, Li Y-SJ,Chien S,Wang N. MicroRNA-19a mediates the suppressive effect of laminar flow on Cyclin D1 expression in HUVEC.Proc Natl Acad Sci USA. 2010; 107:3240-3244

33. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S,Wang N, Shyy JY, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth.Proc Natl Acad Sci U S A. 2010;107:3234-3239

34. Xu G, Li Y, An W, Zhao J, Xiang X, Ding L, Li Z, Guan Y, Wang X, Tang C, Zhu Y,Wang N, Li X, Mulholland M, Zhang W. Regulation of gastric hormone by systemic rapamycin.Peptides. 2010;31:2185-92.

35. Tian J, Wong WK, Tian XY, Zhang P, Huang Y,Wang N. Rosiglitazone attenuates endothelin-1-induced vasoconstriction by upregulating endothelial expression of endothelin B receptor.Hypertension. 2010; 56: 129-35

36. Tsai MC, Chen L, Zhou J,Tang Z, Hsu TF, Wang Y, Shih YT,Peng HH,Wang N, Guan Y, Chien S, Chiu JJ. Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via PPAR-a/d activations by prostacyclin released by sheared endothelial cells.Circ Res, 2009; 105:417-480

37. Zhang P, Wang Y, Fan Y, Tang Z,Wang N. Overexpression of adiponectin receptors potentiates the anti-inflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells.ArteriosclerThrombVasc Biol. 2009; 29:67-74

38. Wang L, Zheng J, Bai X, Liu B, Liu CJ, Xu Q, Zhu Y,Wang N, Kong W, Wang X.ADAMTS-7 mediates vascular smooth muscle cell migration and neointimaformation in balloon-injured rat arteries.Circ Res.2009; 104:688-698

39. DangH, Pang W, Liu Y,Wang N, Shyy JY-J, Zhu Y. Suppression of 2,3-Oxidosqualene cyclaseby high-fat diet contributes to liver X receptor-a-mediated improvement of hepatic lipid profile.J Biol Chem. 2009; 284:6218-26

40. Zhang P, Wang H, Min X, Wang Y, Tang J, Cheng J, Li D, Chen X, Cheng F,Wang N, Yang H. Pim-3 is expressed in endothelial cells and promotes vascular tube formation.J Cell Physiol. 2009; 220:82-90

41. Xu G, Li Y, An W, Li S, Guan Y,Wang N, Tang C, Wang X, Zhu Y, Li X, Mulholland MW, Zhang W. Gastric mTOR signaling regulates ghrelin production and food intake.Endocrinology. 2009;150:3637-44

42. Chen L, Yang G, Zhang X, Wu J, GuQ, Wei M, Zhu Y,Wang N, Guan Y. Induction of MIF expression by oxidized LDL via activation of NF-κB in vascular smooth muscle cells.Atherosclerosis. 2009; 207: 428-33

43. Young A, Wu W, Sun W, Larman H,Wang N, Li Y-S, Shyy J-Y, Chien S, Garcia-Cardena G. Flow-mediated activation of AMP-activated protein kinase regulates Krüppel-like factor 2 Expression in vascular endothelial cells.ArteriosclerThrombVasc Biol.2009;29:1902-8

44. Qin X, Xue XF, Fan Y, Tian J, Guan Y, Wang X, Zhu Y,Wang N. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice.Hepatology.2008; 48:432-41

45. Zhu M, Fu Y,Wang N, Guan Y, Tang CS, Shyy J.Y-J.,Zhu Y. Laminar shear stress regulates liver X receptor in vascular endothelial cells in vitro and in vivo.ArterioThrombVasc Biol.2008;28:527-33

46. Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S,Wang N. Klotho is a target gene of PPAR-gamma.Kidney Intl. 2008; 74:732-9

47. Tang Z, Wang Y, Fan Y, Zhu Y, Chien S andWang N. Suppression of c-Cbl tyrosine phosphorylation inhibits proliferation and migration of vascular smooth muscle cellsin vitro and neointima formation inballoon-injured rat arteries.Circulation. 2008; 118:764-72

48. Li Y, Jiang C, Xu G,Wang N, Zhu Y, Tang C, Wang X. Homocysteineupregulatesresistin production from adipocytes in vivo and in vitro.Diabetes. 2008;57:817-27

49. Zhou Y, Zhang X, Chen L, Wu J, DangH, Wei M, Fan Y, Zhang Y, Zhu Y,Wang N, Breyer M, Guan Y. Expression profiling of hepatic genes associated with lipidmetabolism in nephrotic rats.Am J Physiol Renal Physiol.2008; 295:F662-71

50. Fan Y, Wang Y, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S,Wang N.Suppression of pro-inflammatory adhesion molecules by PPAR-d in human vascular endothelial cells.ArteriosclerThrombVasc Biol. 2008;28:315-2

51. Hao G, Niu X, Gao D, Wei J,Wang N. PPAR-gligands suppress angiotensin II-induced plasminogen activator inhibitor-1 andextracellular matrix production in rat cardiac fibroblasts.Brit J Pharmacol. 2008; 153:1409-1419

52. Wang N. PPAR-d in Vascular Pathophysiology.PPAR Res. 2008; PMID: 19132133

53. Li J,Wang N.Peroxisome proliferator-activated receptor-gamma in vascular biology.CardiovascHematolDisord DrugTargets. 2007;7:109-17

54. Gao D, Niu X, Hao G, Peng N, Wei J, Ning N,Wang N.Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells-role of PPAR-g in vascular fibrosis.BiochemPharmacol. 2007; 73:185-97

55. Ai D, Fu Y, Guo DL, TanakaH,Wang N, Tang CS, HammockBD, Shyy JY-J, Zhu Y. Angiotensin II upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.ProcNatlAcadSci USA. 2007; 104:9018-9023

56. Chen M, Li W,Wang N, Zhu Y, Wang X.ROS and NF-kB but not LXR mediate IL-1b signaling for the downregulation of ATP-binding cassette transporter A1.Am J Physiol Cell Physiol. 2007;292:C1493-501

57. Qin X, Tian J, Zhang P, Fan Y, Chen L, Guan Y, Fu Y, Zhu Y, Chien S,Wang N.  Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells.Cardiovasc Res.2007; 74:506-14

58. Dwarakanath RS, Sahar S, Lanting L,Wang N, Stemerman MB, Natarajan R, Reddy MA. Viral vector mediated 12/15-lipoxygenase overexpression in vascular smooth muscle cells enhances inflammatory gene expression and migration.J Vasc Res. 2007; 45:132-142

59. Ball A, Wang J, Wong S, Zielnik B, Mitchell JM,Wang N, Stemerman MB and Mitchell BF. Phorbol ester treatment of human myometrial cells suppresses expression of oxytocin receptor through a mechanism not involving activator protein-1.Am JPhysiolEndocrinolMetab. 2006; 291:E922-8.

60. WuC, LiY, HagaJ,Wang N, Lian I, Su F, UsamiS and S Chien. Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow.J Cell Biochem. 2006; 98:632-41

61. Dai J, LiW, Chang L, Zhang Z, Tang C,Wang N, Zhu Y, Wang X.  Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis.  Free Radical BiolMed  2006;41:1566-1577

62. WangN,  MiaoH,  LiYS, ZhangP, HagaJH,  HuY, YoungA, YuanS,  NguyenP,  WuCC, ChienS.Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific.BiochemBiophys ResCommun. 2006; 341:1244-1251

63. WuX, MaJ, HanJD,WangN,  ChenYG. Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors.MicrovascRes.2006;71:12-9

64. Yan H, Guo Y, Zhang P, Zu L, Dong X, Chen L, Tian J, Fan X,Wang N,Wu X,Gao W. Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped vectors.BiochemBiophys ResCommun. 2005; 26:336:287-298

65. ZhuY, Liao H, Xie XF, Yuan Y, LeeT-S,Wang N, Wang X, Shyy J.Y-J, Stemerman MB.Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting LXR.Cardiovas Res 2005; 68:425-432.

66. LiuY, Zhu Y, Rannou F, Formentin K, Zeng LF, Yuan X, Forman BM,Wang N, Chien S, Shyy J Y-J. Shear stress increases the endothelial release of ligands for peroxisome proliferator-activated receptor-gamma.Circulation2004; 110:1128-33

67. Wu J, Zhang Y,Wang N, Davis L, Yang G, Wang X, Zhu Y, Breyer MD, Guan Y. Liver X receptor alpha mediates cholesterol efflux in glomerular mesangialcells.Am J Physiol Renal Physiol.2004; 287:F886-895

68. Wang N, Verna L, Chen N, ChenJ, Li H, Forman BM, Stemerman MB. Constitutive activation of PPAR-gamma suppresses expression of adhesion molecules in vascular endothelial cells.  J BiolChem 2002; 277: 34176-34181

69. Yuan Y, Verna L, Wang N, Liao H, Ma K, Wang Y, Zhu Y, Stemerman MB. Cholesterol  enrichmentinduces intercellular adhesion molecule-1 in human vascular endothelial cells.BiochimicaetBiophisicaActa. 2001; 1534: 139-48

70. Wang N, Verna L, Zhu Y, Liao H, Ballard A, Stemerman MB. Adenovirus-mediated overexpression of a dominant negative mutant of c-Jun prevents intercellular adhesion molecule-1 induction by LDL-acritical role for AP-1 in endothelial activation.ArteriosclerThrombVasc Biol. 2001; 21: 1414-1420

71. Wang N, Stemerman MB.Ref-1 and transcriptional control of endothelial apoptosis.Circ Res 2001; 88:1223-1225

72. Zhu Y, Liao H,Wang N, Ma K, Verna L, Shyy J, Chien S, Stemerman MB. Low-density lipoprotein-activated p38 is mediated by ras.ArteriosclerThrombVasc Biol. 2001; 21:1159

73. Liao HL, Zhu Y,Wang N, Verna L, Stemerman MB. Selective activation of endothelial cells by the antioxidant pyrrolidinedithiocarbamate: Involvement of c-Jun and Jun N-terminal kinase activation.Endothelium 2000; 7:121-133

74. Zhu Y, Liao H,Wang N, Yuan Y, Ma K, Verna L, Stemerman MB. Lipoprotein promotes caveolin-1 and rastranslocation to caveolae. Role of cholesterol in endothelial signaling.ArteriosclerThrombVasc Biol. 2000; 20:2465-2470

75. Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Ma KS, Stemerman MB. Adenovirus-mediated overexpression of c-jun and c-fosinduces intercellular adhesion molecule-1 and monocyte chemo-attractant protein-1 in human endothelial cells.ArteriosclerThrombVasc Biol. 1999; 19:2078-2084

76. Wang N, Verna L, Hardy S, MaK, ZhuY, Birrer MJ, Stemerman MB. c-Jun triggers apoptosis in human vascular endothelial cells.Circ Res. 1999; 85: 387-393

77. Zhu Y, LiaoHL,Wang N, Friedli O, Verna L, Stermerman MB. Low-density lipoprotein activates Jun N-terminal kinase (JNK) in human endothelial cells.Biochimica et BiophisicaActa 1999; 1436:557-64

78. FarthmannB,EberleJ, KrasagakisK, GstottnerM,WangN, BissonS,  OrfanosCE. RT-PCR for tyrosinase-mRNA-positive cells in peripheral blood: evaluation strategy and correlation with known prognostic markers in 123 melanoma patients. JInvest Dermatol.1998; 110:263-267

79. EberleJ,GarbeC,WangN, OrfanosCE. Incomplete expression of the tyrosinase gene family (tyrosinase, TRP-1, and TRP-2) in human malignant melanoma cells in vitro.Pigment Cell Res.1995; 8:307-313

 

Research Projects/Grants

 

1. The national natural science foundation of major international (regional) cooperation and exchange programs (30881220108005), the regulation of blood flow shear stress on vascular endothelial cell detoxification mechanisms, 2013.01 to 2017.12, 3 million yuan, the project director
2. The key project of national natural science foundation of China (31430045), the interaction - adipose tissue macrophages regulating the body's sensitivity to insulin and sugar
2015.01-2019.12, in the molecular mechanism of the state of 3.4 million yuan, the project director
3. The national natural science fund project (81470373), fat cells mirnas exocrine body mediated rosiglitazone promote the new mechanism of myocardial hypertrophy, 2015.01 to 2018.12, 730000 yuan, the project director