Education/Working Experience

2007.08-2008.04 visiting scholar

Department of Hematology and Cancer, University of Pittsburgh, USA.

Participation in the Academic Community

Reviewer of Journalof Diabetes、Frontiers in Nephrology and etc.

Editorial board of Journal of Pediatrics and Nutrition

Publication

1.Zhang Y#, Zhang X#, Chen L, Wu J, Lu W J, Hwang M T, Yang G, Li S, Wei M, Davis L, Breyer M D, Guan Y*. Liver X Receptor (LXR) Agonist TO901317 Upregulates SCD1 Expression in Renal Proximal Straight Tubule. Am. J. Physiol. (Renal Physiol). 2006; 290: 1065-1073
2.Park C W, Zhang Y, Zhang X, Wu J, Chen L, Cha D R, Su D, Hwang M T, Fan X, Davis L, Striker G, Zheng F, Breyer M, Guan Y*. PPAR agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int. 2006; 69: 1511-1517
3.Yu B, Wu J, Zhang X, Chen LH, Yang GR, Wei MF, Xing CY, Guan YF*. Liver X receptors mediate cholesterol efflux in mouse glomerular mesangial cells. Beijing Da XueXueBao. 2006 Jun 18;38(3):244-8;
4.Yang G, Chen L, Zhang Y, Zhang X, Wu J, Li S, Wei M, Zhang Z, Breyer MD, Guan Y*. Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract. BiochimBiophysActa. 2006;1761(12):1459-68;
5.Cha DR, Zhang X, Zhang Y, Wu J, Su D, Han JY, Fang X, Yu B, Breyer MD, Guan Y*. Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice. Diabetes. 2007;56(8):2036-45
6.Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD*. Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. J Clin Invest. 2007;117(9):2496-505;
7.Yu S, Franceschi RT, Luo M, Zhang X, Xiao G*. Parathyroid Hormone Increases Activating Transcription Factor 4 Expression and Activity in Osteoblasts: Requirement for Osteocalcin Gene Expression. Endocrinology. 2008:149(4):1960-8;
8.Zhang X, Yu S, Galson DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G*. Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. Journal of Cellular Biochemistry. 2008:26;105(3):885-895 ;
9.Yang J, Chen L, Zhang X, Zhou Y, Zhang D, Huo M, Guan Y*. PPARs and female reproduction: Evidence from genetically manipulated mice. PPAR Research. 2008;2008:723243 (invited review);
10.Zhou Y, Wu J, Zhang X, Yang G, ChenL, Wei M, Zhang Y, Breyer MD, Guan Y*. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am. J. Physiol.-Renal Physiol. 2008;295(3):F662-71;
11.Yang J, Chen L, Zhang X, Zhou Y, Zhang D, Huo M, Guan Y*. PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice. PPAR Res. 2008:723243;
12.Yang J, Zhang D, Li J, Zhang X, Fan FL and Guan Y*. Role of PPARγ in renoprotection in type 2 diabetes: molecular mechanisms and therapeutic potential. Clinical Science 2009;116(1):17-26;
13.Wu J, Chen L, Zhang D, Huo M，Zhang X*, Pu D and Guan Y*. Peroxisome proliferator-activated receptors and renal diseases.Frontiners in Bioscience.2009;14:995-1009;
14.Chen L, Yang G, Zhang X, Wu J, Gu Q, Wei M, Zhu Y, Wang N, Guan Y*. Induction of MIF expression by oxidized LDL via activation of NF-κB in vascular smooth muscle cells. Atherosclerosis 2009;207(2):428-33;
15.Zhang D, Chen L, Zhang Y, Yang G, Qia, Gao Y, Zhang X, Kong X, Wei M, Pu D, Breyer MD, Guan Y*. Enhanced Pressor Action of Angiotensin II in Mice Lacking Membrane-Associated Prostaglandin E2 Synthase-1.ActaPharmacologicaSinica 2010;31(10):1284-92 2010;
16.Cao H, Yu S, Yao Z, Galson DL., Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu Y, Kurihara N, Patrene K, Roodman GD, Xiao G *. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010;120(8):2755-66;
17.Zhou Y, Kong X, Zhao P, Yang H, Chen L, Miao J, Zhang X, Yang J, Ding J, Guan Y*. Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury.Kidney Int. 2011;79(12):1302-11;
18.Han Q#, Zhang X#, Xue R, Yang H, Zhou Y, Kong X, Zhao P, Li J, Yang J, Zhu Y, Guan Y*.AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells.J Am Soc Nephrol. 2011;22:1897-911 (equal contribution);
19.Zhang X#,Liu J#, Su W, Wu J, Wang C, Kong X, Gustafsson JA, Ding J, Ma X, Guan Y*. Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXR-SREBP1c-dependent mechanism. J Diabetes.  2013. doi: 10.1111/1753-0407.12081;
20.Zhang X #, Huang S #, Gao M, Liu J, Jia X, Han Q, Zheng S, Miao Y, Li S, Weng H, Xia X, Du S, Gustafsson J-Å, Guan Y*. Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice. ProcNatlAcad Sci. 2014;111(6):2277-82;
21.Li X#, Zhang X#, Li X, Wang X, Wang S, Ding J*. Cyclosporine A protects podocytes via stabilization of cofilin-1 expression in the unphosphorylated state. ExpBiol Med (Maywood). 2014;239(8):922-936;
22. Zheng S, Liu J, Han Q, Huang S, Su W, Fu J, Jia X, Du S, Zhou Y, Zhang X, Guan Y*. Metformin Induces Renal Medullary Interstitial Cell Apoptosis in Type 2 Diabetic Mice. J Diabetes.  2014;6(2):132-46;
23.Wang C, Chi Y, Li J, Li S, Su W, Jia S, Chen Z, Miao Y, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J ，Guan Y*. FAM3A activates PI3K p110a/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. Hepatology. 2014;59(5):1779-90 ;
24.Li X, Zhang X, Li X, Ding F, Ding J*. The role of survivin in podocyte injury induced by puromycinaminonucleoside. Int J Mol Sci. 2014;15(4):6657-73;
25.Su W, Wang Y, Jia X, Wu W, Li L, Tian X, Li S, Wang C, Xu H, Cao J, Han Q, Xu S, Chen Y, Zhong Y, Zhang X, Liu P, Gustafsson JÅ, Guan Y.Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.ProcNatlAcadSci U S A. 2014;111(31):11437-42; 
26.Chen X, Jiang D, Wang J, Chen X, Xu X, Xi P, Fan Y, Zhang X, Guan Y. Prostaglandin E2 EP1 receptor enhances TGFβ1-induced mesangial cell injury. Int J Mol Med. 2015;35(1):285-93;
27.Zhou Y, Zhang X, Guan Y. HuR: A Novel Therapeutic Target for Diabetic Nephropathy?J Diabetes. 2014 Nov 11. doi: 10.1111/1753-0407.12242. [Epub ahead of print]; 
28.Gao M, Cao R, Du S, Jia X, Zheng S, Huang S, Han Q, Liu J, Zhang X, Miao Y, Kang J, Gustafsson J-Å, Guan Y. Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration viadecreasing aquaporin 2 in renal collecting ducts. Proc Natl Acad Sci U S A. 2015 Jun 22.
29.Zhang X, Liu J,Yang J, Guan Y. Fam3A and Fam3B are a pair of Yin-Yang regulators of hepatic glucose and lipid metabolism. J Mol Cell Biol 2015 (accepted) (invited review).

Research Projects/Grants

2013.01-2015.12

The role and mechanism of bile acid receptor FXR in the regulation of renal sodium metabolism (National Natural Science Foundation of China)

2015. 01-2016.12

The role and mechanism of PPARβ/δ in the development of diabetic nephropathy (Shenzhen Municipal Bureau Committee)