About IEC

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Huihua Li

Title: Professor
Email: hhli1935@aliyun.com
Major: hhli1935@aliyun.com

Education Background

1983.09-1988.07: Shandong Medical University, School of Public Health, Bachelor of Science 1988.09-1991.07: Shandong Academy of Medical Sciences, Occupational Health and Industrial Toxicology,Master of Science 
1995.09-1998.07: Peking Union Medical Collage, Department of Pathology,PhD in Medicine

Working Experience

1991.09-1995.08: Shandong Providence Hospital, Shangdong University, Resident    
1998.09-2002.07: Department of Pathology, Wake Forest University, USA, Post Doc
2002.08-2005.08: Cardiovascular Research Center, University of North Carolina at Chapel Hill, USA, Research Assistant
2005.09-2010.02: Department of Pathology, Peking Union Medical Collage, China, Professor
2010.03-2014.12: Department of Physiology and Pathology, Capital University of China, Professor
2015.01-Present: Institute of Cardiovascular Disease, Dalian Medical University, China,

 Research Projects

1. 2017.01-2021.12: National Science Foundation of China, Key Program. Mechanisms of chemokines/Receptors in regulating of heart failure (81630009)
2. 2014.01-2018.12: National Science Foundation of China, Key Program. Role of ubiquitination-mediated protein degradation in cardiac hypertrophy (81330003)
3. 2016.01- 2019.12: National Science Foundation of China. Mechanisms of deubiquitination UCHL1 in regulating of heart failure (31571170)
4. 2011.01-2014.2:National Science Foundation for distinguished Young Scholars. Pathophysiological mechanism of heart failure (81025001)
5. 2012.01-2017.12: The National Basic Research Program of China (973). Environmental metabolism promotes hypertension via activation of inflammatory responses (2012CB517802)
6. 2006.01-2011.12:The National Major Program. The mechanism of protein active degradation (2006CB910306)

Honors and Awards
2015:Climbing Scholar in Liaoning Provenience
2013:The National Key Talent Project (No.130009)
2012:The Ministry of education of Yangtze River scholar Professor(No.T2011160)
2010:National Science Foundation for distinguished Young Scholars

Social Positions

2015-Present: Section of Clinical Trial and Big Data Quality Control, Society of China Quality Association for Pharmaceuticals, Deputy Chair 
2015-Present: Peripheral Vessel Section, Society of Chinese Microenvironment, Committee Member
2011-Present: Lipid and lipoprotein section, Society of Chinese biochemistry and molecular biology
2014-Present: Chinese Society of Pathophysiology, Committee Member of the Eighth Session 
2014-Present: ISHR of Chinese Section, Committee Member of the Sixth Session             

Published Papers

1. Lei Wang, Xue-Chen Zhao, Wei Cui, Yong-Qiang Ma, Hua-Liang Ren, Xin Zhou, Yan-Zong Yang, Yun-Long Xia*, Jie Du, Hui-Hua Li*. Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction. Circulation. 2016;134:1353–1368. (IF=17.047)
2. Lei Wang, Tian-Peng Zhang, Yuan Zhang, Hai-Lian Bi, Xu-Min Guan, Hong-Xia Wang, Xia Wang, Jie Du, Yun-Long Xia*, Hui-Hua Li*. Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein. Scientific Reports. 2016; 6:28399. (IF=5.228)
3. Cai-xia Guo, Xue Jiang, Xiang-jun Zeng, Hong-xia Wang, Hui-hua Li, Feng-he Du, Bu-xing Chen. Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system. Free Radical Biology and Medicine. 2016; 94:17–26. (IF=5.784) 
4. Xia Wang, Hong-Xia Wang, Yu-Lin Li, Cong-Cong Zhang, Chun-Yu Zhou, Lei Wang, Yun-Long Xia, Jie Du, Hui-Hua Li*. MicroRNA Let-7i Negatively Regulates Cardiac Inflammation and Fibrosis. Hypertension. 2015;66:776-785. (IF=6.48)
5. Nan Li, Hong-Xia Wang, Qiu-Yue Han, Jie Du, Yun-Long Xia*, Hui-Hua Li*. Activation of the Cardiac Proteasome Promotes Angiotension II-Induced Hypertrophy by Down-regulation of ATRAP. J Mol Cell Cardiol. 2015 Feb;79:303-14.(IF=4.655)
6. Yan Ma, Chen Zhang, Xiao-Bo Gao, Hai-Yan Luo, Yang Chen, Huihua Li*, Xu Ma*, Cai-Ling Lu*. Folic acid protects against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1. Scientific Reports. 2015,Nov 5;5:16093.. (IF=5.578) 
7. Hualiang Ren, Fangda Li, Cui Tian, Hao Nie, Lei Wang, Hui-Hua Li*, and Yuehong Zheng*. Inhibition of Proteasome by Low-dose bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E-/- Mice. Scientific Reports. 2015 Oct 28;5:15730. (IF=5.578) 
8. Qiu-Yue Han, Hong-Xia Wang, Xiao-Hong Liu, Cai-Xia Guo, Qi Hua, Xiao-Hong Yu, Nan Li, Yan-Zong Yang, Jie Du, Yun-Long Xia*, and Hui-Hua Li*. Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction. Clinical Science(Lond)2015 Jun;128(11):751-60.(IF=5.598)
9. Yan Liu, Ying Wang, Hongtao Shi, Lixin Jia, Jizhong Cheng, Wei Cui, Huihua Li, Ping Li, Jie Du. CARD9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts. Cardiovasc Res. 2015 Oct 1;108(1):148-58. (IF=5.94)
10. Hui Yang, Nan Li, Li-Na Song, Lei Wang, Cui Tian, Chao-Shu Tang, Jie Du, and Hui-Hua Li . Xiao-Hong Yu* and Hong-Xia Wang*. Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways. Apoptosis, 2015 Apr;20(4):512-22.(IF=3.685)
11. Lei Wang, Yu-Lin Li, Cong-Cong Zhang, Wei Cui, Xia Wang, Yong Xia, Jie Du*, Hui-Hua Li*. Inhibition of Toll-Like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation. Cardiovascular Research. 2014 Mar;101(3):383-92. (IF=5.94) 
12. Wei Zhao, Yulin Li, Lili Pan, Hui-Hua Li*, Jie Du*. Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin. Free Radical Biology & Medicine, 2014; 69: 108-115. (IF=5.736)
13. Hong-Tao Shi, Ying Wang, Li-Xin Jia, Yan-Wen Qin, Yan Liu, Hui-Hua Li, Yong-Fen Qi, Jie Du*. Cathepsin S Contributes to  Macrophage Migration via Degradation of Elastic Fiber Integrity to Facilitate Vein Graft Neointimal Hyperplasia. Cardiovascular Research. 2014, Mar 1;101(3):454-63. (IF=5.94)
14. Yina Wu, Yulin Li, Congcong Zhang, Xi A, Yueli Wang, Wei Cui, Huihua Li, Jie Du*. S100a8/a9 Released by CD11b+Gr1+ Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II-Induced Cardiac Inflammation and Injury. Hypertension.2014;63:1241-1250. (IF=6.48)
15. Feifei Ma, Jin Feng, Chao Zhang,1 Yulin Li, Guanming Qi, Huihua Li, Yuzhang Wu, Yangxin Fu, Yang Zhao, Hairong Chen, Jie Du* and Hong Tang*. The Requirement of CD8+ T Cells To Initiate and Augment Acute Cardiac Inflammatory Response to High Blood Pressure. J Immunol. 2014 Apr 1;192 (7):3365-73. (IF=5.362)
16. Congcong Zhang, Yulin Li, Chunxiao Wang,  Yina Wu, Wei Cui, Takashi Miwa, Sayaka Sato,  Huihua Li,  Wen-Chao Song*,  Jie Du*. Complement C5a receptor mediates Ang II-induced cardiac inflammation and remodeling. Arterioscler. Thromb. Vasc. Biol. 2014; 34: 1240-1248.(IF=5.533)
17. Chen Chen, Yan Meng, Lei Wang, Hong-Xia Wang, Cui Tian, Guo-Dong Pang, Hui-Hua Li*, Jie Du*. Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IkBa/NF-kB and MKP1/ERK/STAT1 pathways. Immunology. 2014 142, 307-319. (IF=3.705)
18. Hong-Xia Wang, Hui Yang, Qiuyue Han, Nan Li, Xue Jiang, Cui Tian, Jie Du*, Huihua Li*. NADPH oxidases mediate a cellular 'memory' of angiotensin II stress in hypertensive cardiac hypertrophy. Free Radical Biology & Medicine, 2013. pp. 897-907. (IF=5.71) 
19. Qin Y, Cao X, Guo J, Zhang Y, Pan L, Zhang H, Li H, Tang C, Du J, Shi GP*. Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovascular Research. 2012,Dec;96 (3): 401-10. (IF=5.808) 
21. Li Y, Zhang C, WU Y, Han Y, Cui W, Jia L, Cai L, Cheng J, Li H, Du J*. Interleukin-12p35 Deletion Promotes CD4 T-Cell–Dependent Macrophage Differentiation and Enhances Angiotensin II–Induced Cardiac Fibrosis. Arterioscler. Thromb. Vasc. Biol. 2012 Jul;32(7):1662-74. (IF=5.533)
22. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J*. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler. Thromb. Vasc. Biol. 2012 Jul;32(7):1675-86.(IF=5.533)
23. Zhang Y, Zeng Y, Wang M, Tian C, Ma X, Chen H, Fang Q, Jia L, Du J, and Li H*. Cardiac-specific overxpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury. Basic Research in Cardiology. 2011, 106(3):371-83. (IF=5.955)
24. Kang YM#*, Gao F#, Li HH#, Cardinale JP, Elks C, Zang WJ, Yu XJ, XU YY, Qi J, Yang Q, and Francis J. NF-kB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in the heart. Basic Research in Cardiology. 2011 Nov;106(6):1087-97. (IF=5.955) 
25. Li H*, Du J, Fan Y, Zhang M, Liu D, Li L, Lockyer P, Kang E, Patterson C, Willis MS*. The ubiquitin ligase Muscle Ring Finger-1 (MuRF1) protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun. Am J Pathology. 2011. Mar;178(3):1043-58.(IF=4.522)  
26. Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J*. The Mechanical Stress-Activated Serum-, Glucocorticoid-Regulated Kinase 1 Contributes to Neointima Formation in Vein Grafts. Circulation Research. 2010; 107;1265-1274.(IF=11.089) 
27. Yang D., Xie P, Guo S, Li H*. Induction of MAPK phosphatase-1 by hypothermia inhibits tumor necrosis factor-alpha-induced endothelial barrier dysfunction and apoptosis. Cardiovascular Research. 2010 Feb 1;85(3):520-529.(IF=5.808) 
28. Xie P, Guo S, Fan Y, Zhang H, Gu D, Li H*.  Atrogin-1/MAFbx enhances simulated Ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAP kinase phosphatase-1 and sustained JNK activation. J. Biol. Chem. 2009; 284(9):5488-5496.(IF=4.651)  
29. Xie P, Fan Y, Zhang H, Zhang Y, She M, Gu D, Patterson C, and Li H*. CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. Mol. Cell Biol. 2009; 29 (9):2398-2408.(IF=5.372) 
30. nte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass and Cam Patterson*. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J. Clinical Investigation. 2007;117(11): 3211–3223.(IF=13.612)
31. Hui-Hua Li, Vishram Kedar, Chunlian Zhang, Holly McDonough, Ranjana Arya, Da-Zhi Wang, and Cam Patterson. Atrogin-1/ muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J. Clinical Investigation. 2004;114; 1058-1071.(IF=13.612)