About IEC

Home | About IEC | Faculty | 正文

Lihong Chen

Title: Professor
Email: lihongch@mail.med.upenn.edu
Major: Translational Medicine

    Education/Working Experience


    2009.7 – 2014.6 Postdoctoral Researcher

    2014.7 – now Research Associate

    Institute for Translational Medicine and Therapeutics, Department of Systems Pharmacology andTranslational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA19104


    Participation in the Academic Community


    Member of American Heart Association (AHA)

    Member of American Pain Association (APS)




    1. Anne M. Curtis, Caio T. Fagundes, Guangrui Yang, Eva M. Palsson-McDermott, Paulina Wochal, Anne F. McGettrick,Niamh H. Foley, James O. Early, Lihong Chen, Hanrui Zhang, ChenyiXue, Sarah S. Geiger, KarstenHokamp,Muredach P. Reilly, Andrew N. Coogan, Elena Vigorito, Garret A. FitzGerald, and Luke A. J. O’Neill. Circadian controlof innate immunity in macrophages by mir-155 targeting bmal1. ProcNatlAcad Sci. 2015, 112(23): 7231-7236.

    2. Lihong Chen (*co-corresponding author), and Guangrui Yang*: Recent Advances in Circadian Rhythms inCardiovascular System. Front Pharmacol. 2015, 6: 71.

    3. Lihong Chen, Guangrui Yang, James Monslow, Leslie Todd, David P. Cormode, Jun Tang, Gregory R. Grant, JonathanH. DeLonge, Soon Yew Tang, John A. Lawson, Ellen Pure, and Garret A. FitzGerald: Myeloid cell microsomalprostaglandin E synthase-1 fosters atherogenesis in mice. ProcNatlAcad Sci. 2014, 111(18): 6828-6833.

    4. Lihong Chen* (*co-corresponding author), ZhanjunJia and Guangrui Yang*: PPARs and metabolic syndrome.PPAR Res. 2014, 2014: 832606.

    5. Lihong Chen* (*co-corresponding author), and Guangrui Yang*: PPARs integrate the mammalian clock and energymetabolism. PPAR Res. 2014, 2014: 653017.

    6. Lihong Chen, Guangrui Yang, Xiufeng Xu, Gregory Grant, John A. Lawson, Mohammad Bohlooly-Y and Garret A.FitzGerald: Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 2013, 127(2):233-243.

    7. Lihong Chen, Yifei Miao, Yahua Zhang, Dou Dou, Limei Liu, XiaoyuTian, Guangrui Yang, Dan Pu, Xiaoyan Zhang,Jihong Kang, Yuansheng Gao, Shiqiang Wang, Matthew D. Breyer, Nanping Wang, Yi Zhu, Yu Huang, Richard M. Breyer and Youfei Guan: Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressorpesponse viadecreasing arterial contractility. ArteriosclerThrombVasc Biol. 2012, 32(12): 3024-3032.

    8. Lihong Chen, Guangrui Yang and Tilo Grosser: Prostanoids and inflammatory Pain. Prostaglandins Other LipidMediat. 2013, 104-105: 58-66.

    9. Yunfeng Zhou, Xiaomu Kong, Pan Zhao, Hang Yang, Lihong Chen, Jing Miao, Xiaoyan Zhang, Jichun Yang, Jie Dingand Youfei Guan: Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. KidneyInternational. 2011, 79 (12): 1302-1311.

    10. Miao Wang, Kaori Ihida-Stansbury, DevashishKothapalli, Mathieu C. Tamby, Zhou Yu, Lihong Chen, Gregory Grant,Yan Cheng, John A. Lawson, Richard K. Assoian, Peter L. Jones, and Garret A. FitzGerald: Microsomal prostaglandinE2 synthase-1 modulates the response to vascular injury. Circulation. 2011, 123(6): 631-639.

    11. Fenling Fan, Aiqun Ma, Youfei Guan, JianhuaHuo, Zhi Hua, HongyanTian, Lihong Chen, Sen Zhu, Lihong Fan:Effect of PGE2 on DA tone by EP4 modulating Kv channels with different oxygen tension between preterm and term.Int J Cardiol. 2011, 147(1): 58-65.

    12. Dongjuan Zhang, Hang Yang, Xiaomu Kong, Kang Wang, Xuan Mao, Xianzhong Yan, Yuan Wang, Siqi Liu, XiaoyanZhang, Jing Li, Lihong Chen, Jing Wu, Mingfen Wei, Jichun Yang, and Youfei Guan: Proteomics analysis revealsdiabetic kidney as a ketogenic organ in type 2 diabetes. Am J PhysiolEndocrinolMetab. 2011, 300(2): E287-295.

    13. Dongjuan Zhang, Lihong Chen, Yahua Zhang, Guangrui Yang, Dou Dou, Yuansheng Gao, Xiaoyan Zhang, XiaomuKong, Pan Zhao, Dan Pu, Mingfen Wei, Matthew D. Breyer and Youfei Guan: Enhanced pressor response to acute AngII infusion in mice lacking membrane-associated prostaglandin E2 synthase-1. ActaPharmacol Sin. 2010, 31(10):1284-1292.

    14. Fenling Fan, Sen Zhu, Lihong Chen, YuliangZou, Lihong Fan, Jihong Kang, Aiqun Ma and Youfei Guan: Role ofPGE2 and its receptors in the process of the ductusarteriosus maturation and functional closure in rabbit. ClinExpPharmacol Physiol. 2010, 37(5-6): 574-580.

    15. Ming Huo, HuilingZang, Dongjuan Zhang, Bing Wang, Jing Wu, Xiaoyan Zhang, Lihong Chen, Jing Li, Jichun Yangand Youfei Guan: Role of increased activity of carbohydrate response element binding protein in excessive lipidaccumulation in the liver of type 2 diabetic db/db mouse. Journal of Peking University (Health sciences). 2009, 41(3):307-312.

    16. Lihong Chen, Guangrui Yang, Xiaoyan Zhang, Jing Wu, Qing Gu, Mingfen Wei, Jichun Yang, Yi Zhu, Nanping Wangand Youfei Guan: Induction of MIF expression by oxidized LDL via activation of NF-кB in vascular smooth musclecells. Atherosclerosis. 2009, 207(2):428-433.

    17. Min-Chien Tsai, Lihong Chen, Jing Zhou, Zhihui Tang, Tzu-Fang Hsu, Ying Wang, Yu-Tsung Shih, Hsin-Hsin Peng,Nanping Wang, Youfei Guan, Shu Chien and Jeng-Jiann Chiu: Shear stress induces synthetic-to-contractile phenotypicmodulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclinreleased by sheared endothelial cells. Circ Res. 2009, 105(5): 471-480.

    18. Jing Miao, Qingfeng Fan, Qinghua Cui, Han Zhang, Lihong Chen, Suxia Wang, Na Guan, Youfei Guan and Jie Ding:Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes. NephrolDial Transplant. 2009, 24(11): 3297-3305. 19. Jing Wu, Lihong Chen, Dongjuan Zhang, Ming Huo, Xiaoyan Zhang, Dan Pu and Youfei Guan: Peroxisomeproliferator-activated receptors and renal diseases. Frontiners in Bioscience. 2009, 14: 995-1009.

    20. Jichun Yang, Lihong Chen, Xiaoyan Zhang, Yunfeng Zhou, Dongjuan Zhang, Ming Huo and Youfei Guan: PPARs and female reproduction: Evidence from genetically manipulated mice. PPAR Res. 2008; 2008: 723243.

    21. Yunfeng Zhou, Xiaoyan Zhang, Lihong Chen, Jing Wu, Huaixin Dang, Mingfen Wei, Yanbo Fan, Yahua Zhang, YiZhu, Nanping Wang, Matthew D. Breyer and Youfei Guan: Expression profiling of hepatic genes associated with lipidmetabolism in nephrotic rats. Am J Physiol Renal Physiol. 2008, 295(3): F662-671.

    22. Youfei Guan, Yahua Zhang, Jing Wu, Zhonghua Qi, Guangrui Yang, Dou Dou, Yuansheng Gao, Lihong Chen,Xiaoyan Zhang, Linda S. Davis, Mingfeng Wei, Xuefeng Fan, Monica Carmosino, ChuanmingHao, John D. Imig,Richard M. Breyer and Matthew D. Breyer: Antihypertensive effects of selective prostaglandin E2 recpetor subtype 1targeting. J. Clin. Invest. 2007; 117: 2496-2505.

    23. Lihong Chen, Guangrui Yang and Youfei Guan: PPARα/γ dual agonists and atherosclerosis. Progress in Physiological Sciences. 2007; 38(2): 153-155. (Article in Chinese)

    24. Guangrui Yang, Lihong Chen, Yahua Zhang, Xiaoyan Zhang, Jing Wu, Shuo Li, Mingfen Wei, Zhiwen Zhang,Matthew D. Breyer and Youfei Guan: Expression of mouse membrane-associated prostaglandin E(2) synthase-2(mPGES-2) along the urogenital tract. BiochimBiophysActa. 2006; 1761(12): 1459-1468.

    25. Guangrui Yang, Jing Wu, Lihong Chen and Youfei Guan: Metabolic nuclear receptors and metabolic syndrome. Basicand Clinical Medicine. 2006, 26: 35-41. (Article in Chinese)

    26. Yahua Zhang, Xiaoyan Zhang, Lihong Chen, Jing Wu, Dongming Su, Wendell J. Lu, Mei-Tsuey Hwang, GuangruiYang, Shuo Li, Minfen Wei, Linda Davis, Matthew D. Breyer and Youfei Guan: Liver X receptor agonist TO-901317upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol Renal Physiol. 2006, 290: F1065-1073.

    27. CheolWhee Park, Yahua Zhang, Xiaoyan Zhang, Jing Wu, Lihong Chen, DaeRyong Cha, Dongming Su, Mei-TsueyHwang, Xuefeng Fan, Linda Davis, Gary E. Striker, Feng Zheng, Matthew D. Breyer and Youfei Guan: PPARα agonistfenofibrate improves diabetic nephropathy in db/db mice. Kidney International. 2006; 69: 1511-1517.

    28. Bo Yu, Jing Wu, Xiaoyan Zhang, Lihong Chen, Guangrui Yang, Mingfen Wei, Changying Xing and Youfei Guan:Liver X receptors mediate cholesterol efflux in mouse glomerular mesangial cells. Journal of Peking University (Healthsciences). 2006, 38:244-248. (Article in Chinese)

    29. Lihong Chen and Youfei Guan: Role of macrophage migration inhibitory factor (MIF) in atherosclerosis. Progress inPhysiological Sciences. 2006; 37(1): 45-47. (Article in Chinese)

    30. Xiaoyan Zhang, Lihong Chen and Youfei Guan: PPAR family and its relationship to metabolic syndrome. Progress inPhysiological Sciences. 2005; 36(1): 6-12. (Article in Chinese)


    Research Projects/Grants


    15SDG22780013; American Heart Association Scientist Development Grant2015.1-2017.12Macrophage mPGES-1, a novel therapeutic target for inflammatory diseases; Role: Principal Investigator.