About IEC

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Bo Song

Title: Professor; Vice Dean of IEC
Email: yr0806@hotmail.com; bosong@dmu.edu.cn
Major: Pathology

    Education/Working Experience

    2009.09-2010.07, Research Scientist, Department of Pathology, Stony Brook University, Stony Brook, NY, USA

    2008.09-2009.08, Postdoctoral Fellow, Department of Pathology, Stony Brook University, Stony Brook, NY, USA

    2007.03-2008.08, Postdoctoral Fellow, Cancer Genomics, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

    2005.12-2006.11, Visiting Scholar, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    1998.09-1999.07, Assistant Professor, Department of Pathology, Dalian Medical University, Dalian, P.R.China

    1999.08-2003.06, Associate Professor, Department of Pathology, Dalian Medical University, Dalian, P.R.China

    2003.07-2012.12,  Professor, Department of Pathology, Dalian Medical University, Dalian, P.R.China

    Participation in the Academic Community

    Member, Community of Pathology and Pathophysiology, Dalian Branch of Chinese Medical Association


    1. Li C, Wang Y, Lu S, Zhang Z, Meng H, Liang L, Zhang Y, Song B. MiR-34a

    inhibits colon cancer proliferation and metastasis by inhibiting platelet-derived growth factor receptor α. Mol Med Rep. 2015;12:7072-8. Corresponding author

    2. Mao J, Fan S, Ma W, Fan P, Wang B, Zhang J, Wang H, Tang B, Zhang Q, Yu X, Wang L, Song B, Li L. Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis. 2014; 5: e1039. Co-Corresponding author

    3. Mao J, Song B, Shi Y, Wang B, Fan S, Yu X, Tang J, Li L. ShRNA targeting Notch1 sensitizes breast cancer stem cell to paclitaxel. Int J Biochem Cell Biol. 2013; 45(6): 1064-73. Co-First author

    4. Song B, Wang Y, Titmus MA, Botchkina G, Ju J. Effects of miR-215 on the resistance to chemotherapy in osteosarcoma and colon cancer cells. Molecular Cancer. 2010; 9: 96-105.

    5. Song B, Ju J. Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis. Expert Rev Mol Med. 2010; 12: e33. Review.

    6. Song B, Wang Y, Xi Y, Kudo K, Bruheim S, Botchkina GI, Gavin E, Wan Y, Formentini A, Kornmann M, Fodstad O, Ju J. Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene. 2009; 28: 4065-74.

    7. Song B, Wang Y, Kudo K, Gavin EJ, Xi Y, Ju J. miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. Clin Cancer Res. 2008; 14: 8080-6.

    8. Song B, Margolin S, Skoglund J, Zhou XL, Rantala J, Picelli S, Werelius B, Lindblom A. TGFBR1*6A and Int7G24A variants of transforming growth factor-b receptor 1 in Swedish familial and sporadic breast cancer. Br J Cancer. 2007; 97: 1175-9.

    9. Zhang C, Lu Y, Li Q, Mao J, Hou Z, Yu X, Fan S, Li J, Gao T, Yan B, Wang B, Song B, Li L. Salinomycin suppresses TGF-β1-induced epithelial-to-mesenchymaltransition in MCF-7 human breast cancer cells. Chem Biol Interact. 2016;248:74-81.

    10. Du Y, Huang Y, Gao Y, Song B, Mao J, Chen L, Bai L, Tang J. Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis. Biomed Pharmacother. 2015;74:30-4.

    11. Ma W, Xiao GG, Mao J, Lu Y, Song B, Wang L, Fan S, Fan P, Hou Z, Li J, Yu X,Wang B, Wang H, Wang H, Xu F, Li Y, Liu Q, Li L. Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness. Oncotarget. 2015;6:10432-44.

    12. Kang L, Mao J, Tao Y, Song B, Ma W, Lu Y, Zhao L, Li J, Yang B, Li L.MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. Cancer Sci. 2015;106:700-8.

    13. Zhao W, Zou J, Wang B, Fan P, Mao J, Li J, Liu H, Xiao J, Ma W, Wang M, Li L, Song B. [microRNA-140 suppresses the migration and invasion of colorectal cancer cells through targeting Smad3]. Zhonghua Zhong Liu Za Zhi. 2014;36:739-45. Chinese. Corresponding author

    14. Lu Y, Ma W, Mao J, Yu X, Hou Z, Fan S, Song B, Wang H, Li J, Kang L, Liu P,Liu Q, Li L. Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling. Chem Biol Interact.2015;228:100-7.

    15. Zhai H, Song B, Xu X, Zhu W, Ju J. Inhibition of autophagy and tumor growth in colon cancer by miR-502. Oncogene. 2013; 32(12): 1570-9.

    16. Wang Y, Ma T, Bi J, Song B, Zhou Y, Zhang C, Gao M. RASSF10 is epigenetically inactivated and induces apoptosis in lung cancer cell lines. Biomed Pharmacother. 2013; 68: 321-6

    17. Li CY, Song B, Wang YY, Meng H, Guo SB, Liu LN, Lv HC, Wu QJ. Age at menarche and risk of colorectal cancer: a meta-analysis. PLoS ONE. 2013; 8(6): e65645.

    18. Karaayvaz M, Pal T, Song B, Zhang C, Georgakopoulos P, Mehmood S, Burke S, Shroyer K, Ju J. Prognostic significance of miR-215 in colon cancer. Clin Colorectal Cancer. 2011; 10(4): 340-7.

    19. Louie E, Nik S, Chen JS, Schmidt M, Song B, Pacson C, Chen XF, Park S, Ju J, Chen EI. Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res. 2010;12:R94.

    20. Kudo K, Xi Y, Wang Y, Song B, Chu E, Ju J, Russo JJ, Ju J. Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip). Nucleic Acids Res. 2010; 38(9): e104.

    21. Mishra PJ, Song B, Mishra PJ, Wang Y, Humeniuk R, Banerjee D, Merlino G, Ju J, Bertino JR. MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism. PLoS ONE. 2009; 4: e8445.

    22. Skoglund Lundin J, Vandrovcova J, Song B, Zhou X, Zelada-Hedman M, Werelius B, Houlston RS, Lindblom A. TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk. Br J Cancer. 2009; 100: 1674-9.

    23. Gavin EJ, Song B, Wang Y, Xi Y, Ju J. Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin. PLoS ONE. 2008; 3: e4054.

    24. Skoglund J, Song B, Dalén J, Dedorson S, Edler D, Hjern F, Holm J, Lenander C, Lindforss U, Lundqvist N, Olivecrona H, Olsson L, Påhlman L, Rutegård J, Smedh K, Törnqvist A, Houlston R, Lindblom A. Lack of an association between the TGFBR1*6A variant and colorectal cancer risk. Clin Cancer Res. 2007; 13: 3748-62.

    25. Ju J, Schmitz JC, Song B, Kudo K, Chu E. Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. Clin Cancer Res. 2007; 13: 4245-51.

    26. Cui XN, Song B, Hou L, Wei ZY, Tang JW. High expression of osteoglycin decreases the metastatic capability of mousehepatocarcinoma Hca-F cells to lymph nodes. Acta Biochim Biophys Sin. 2008; 40: 349-55.

    Research Projects/Grants

    1. Grant from the National Natural Science Foundation of China (No. 81172052), Roles and mechanisms of miR-140 in the tumor metastasis, 2012.1-2015.12, Principle Investigator (PI)

    2. Grant from the National Natural Science Foundation of China (No. 81272430), Mechanism of self-renewal regulated by miR-34a in the breast cancer stem cell, 2013.1-2016.12, Co-PI

    3. Grant from the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, Roles and mechanisms of miR-502 in the chemoresistance of doxorubicin, 2013.01-2015.12, PI

    Admission Plan/Requirements

    1, Pathology

    Fluent English, interested in doing research.