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Zhiguang Li

Title: Professor
Email: Zhiguangli2013@126.com
Major: Biochemistry and Molecular Biology

    Education/Professional Experience

    199409 — 199807  China  Wu Han University    Microbiology      B.S.

    199809 — 200107  China  Fu Dan University    Microbiology      M.S.

    200409 — 200807  China  Institute of Biophysics, Chinese Academy of Sciences Biochemistry and Molecular Biology    Ph.D.

    200107—200207  China  YiShengTang Biology Medicine Ltd       Research Scientist

    200207—200407  China  CapitalBio Corporation                  Research Scientist

    200806—201105  USA  National Center for Toxicological Research  Postdoctoral fellow

    201105—201402   USA   Johns Hopkins University     Postdoctoral& Research Scientist

    201402—now     China   Dalian Medical University               Professor

    Participation in the Academic Community

    The Society of Toxicology               2009.09—Present  Member

    Environmental Mutagen Society           2011.01— Present   Member

    Psychoneuroimmunology Research Society  2013.11— Present  Member


    1. Wen, Y., Chen, F., Zhang, Q., Zhuang, Y.,Li Zhiguang: Detection of differentially methylated regions in whole genome bisulfite sequencing data using local Getis-Ord statistics. Bioinformatics, 2016, DOI: 10.1093/bioinformatics/btw497. (IF=5.766)

    2. Zhang, X., Lv, D., Zhang, Y., Liu, Q.,Li Zhiguang: Clonal evolution of acute myeloid leukemia highlighted by latest genome sequencing studies, Oncotarget, 2016, DOI: 10.18632/oncotarget.10850. (IF=5.008)

    3. Lv D, Wang X, Dong J, Zhuang Y, Huang S, Ma B., Chen P., Li X., Zhang C.,Li Zhiguang, Jin, B.: Systematic characterization of lncrnas' cell-to-cell expression heterogeneity in glioblastoma cells. Oncotarget, 7(14), 18403-18414. (IF=5.008)

    4. Li Zhiguang, Qin T, Wang K, et al. Integrated microRNA, mRNA, and protein expression profiling reveals microRNA regulatory networks in rat kidney treated with a carcinogenic dose of aristolochic acid. BMC Genomics, 2015, 16(1):1-11. (IF=3.867)

    5. Li Zhiguang, Dai, H., Martos, S. N., Xu, B., Gao, Y., Li, T., ... & Wang, Z. Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biology, 2015, 16(1):1-15. (IF=10.810)

    6. Li Zhiguang, Su Z, Wen Z, Shi L, Chen T: Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles. BMC bioinformatics 2009, 10 Suppl 11:S12. (IF=3.428)

    7. Li Zhiguang, Chen L, Qin Z: Paradoxical roles of IL-4 in tumor immunity. Cellular & molecular immunology 2009, 6(6):415-422. (IF=2.765)

    8. Li Zhiguang, Jiang J, Wang Z, Zhang J, Xiao M, Wang C, Lu Y, Qin Z: Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer research 2008, 68(21):8687-8694. (IF=7.514)

    9. Li Zhiguang, Pradera F, Kammertoens T, Li B, Liu S, Qin Z: Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection. Journal of Immunology 2007, 179(3):1568-1576. (IF=6.068)

    10. Li Zhiguang, Chen LY, Huang J, Qiao P, Qiu JM, Wang SQ: Quantification of the relative levels of wild-type and lamivudine-resistant mutant virus in serum of HBV-infected patients using microarray. Journal of viral hepatitis 2005, 12(2):168-175. (IF=2.550)

    11. Li Zhiguang, Branham WS, Dial SL, Wang Y, Guo L, Shi L, Chen T: Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea. BMC genomics 2010, 11:609. (IF=4.206)

    12. Li Zhiguang, Fuscoe JC, Chen T: MicroRNAs and their predicted target messenger RNAs are deregulated by exposure to a carcinogenic dose of comfrey in rat liver. Environmental and molecular mutagenesis 2011, 52(6):469-478. (IF=3.709)

    13. Wang, Y.,Li Zhiguang, Chen, T., Zhao, X., Understanding the aristolochic acid toxicities in rat kidneys with regulatory networks. IET Systems Biology, 2015, 9(4), 141-146. (IF=0.764)

    14. Meng F,Li Zhiguang, Yan J, et al. Tissue-specific microRNA responses in rats treated with mutagenic and carcinogenic doses of aristolochic acid. Mutagenesis, 2014, 29(5):357-65. (IF=2.793)

    15. Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E,Li Zhiguang, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B: The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3. Immunity 2013, 39(2):272-285. (IF=19.700)

    16. Meng F, Hackenberg M,Li Zhiguang, Yan J, Chen T: Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation. PloS one 2012, 7(3):e34394. (IF=3.730)

    17. Chen T,Li Zhiguang, Yan J, Yang X, Salminen W: MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver. Mutagenesis 2012, 27(1):59-66. (IF=3.500)

    18. Zhang Y, Xu Y,Li Zhiguang, Chen T, Lantz SM, Howard PC, Paule MG, Slikker W, Jr., Watanabe F, Mustafa T, Biris AS, Ali SF: Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells. ACS nano 2011, 5(9):7020-7033. (IF=11.421)

    19. Su Z,Li Zhiguang, Chen T, Li QZ, Fang H, Ding D, Ge W, Ning B, Hong H, Perkins RG, Tong W, Shi L: Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys. Chemical research in toxicology 2011, 24(9):1486-1493. (IF=3.779)

    20. Mahmood M,Li Zhiguang, Casciano D, Khodakovskaya MV, Chen T, Karmakar A, Dervishi E, Xu Y, Mustafa T, Watanabe F, Fejleh A, Whitlow M, Al-Adami M, Ghosh A, Biris AS: Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation. Journal of cellular and molecular medicine 2011, 15(11):2297-2306. (IF=4.125)

    21. Chen D,Li Zhiguang, Chen T: Increased expression of miR-34a in mouse spleen one day after exposure to N-ethyl-N-nitrosourea. Journal of applied toxicology : JAT 2011, 31(5):496-498. (IF=2.478)

    22. Wang Z, Jiang J,Li Zhiguang, Zhang J, Wang H, Qin Z: A myeloid cell population induced by Freund adjuvant suppresses T-cell-mediated antitumor immunity. J Immunother 2010, 33(2):167-177. (IF=3.593)

    23. Shi L, Campbell G, Jones WD, Campagne F, Wen Z, Walker SJ, Su Z, Chu TM, Goodsaid FM, Pusztai L, Shaughnessy JD, Jr., Oberthuer A, Thomas RS, Paules RS, Fielden M, Barlogie B, Chen W, Du P, Fischer M, Furlanello C, Gallas BD, Ge X, Megherbi DB, Symmans WF, Wang MD, Zhang J, Bitter H, Brors B, Bushel PR, Bylesjo M, Chen M, Cheng J, Cheng J, Chou J, Davison TS, Delorenzi M, Deng Y, Devanarayan V, Dix DJ, Dopazo J, Dorff KC, Elloumi F, Fan J, Fan S, Fan X, Fang H, Gonzaludo N, Hess KR, Hong H, Huan J, Irizarry RA, Judson R, Juraeva D, Lababidi S, Lambert CG, Li L, Li Y,Li Zhiguang, et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nature biotechnology 2010, 28(8):827-838. (IF=31.090)

    24. Ross JA, Blackman CF, Thai SF,Li Zhiguang, Kohan M, Jones CP, Chen T: A potential microRNA signature for tumorigenic conazoles in mouse liver. Molecular carcinogenesis 2010, 49(4):320-323. (IF=3.265)

    25. Jiang J, Wang Z,Li Zhiguang, Zhang J, Wang C, Xu X, Qin Z: Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression. Gene therapy 2010, 17(8):991-999. (IF=4.538)

    26. Xiao M, Wang C, Zhang J,Li Zhiguang, Zhao X, Qin Z: IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer research 2009, 69(5):2010-2017. (IF=70543)

    Li Zhiguang, Kwekel JC, Chen T: Functional comparison of microarray data across multiple platforms using the method of percentage of overlapping functions. Methods Mol Biol 2012, 802:123-139. (Book Chapter)

    Research Projects/Grants

    1. 201401-201612   Liaoning “Climbing” Scholar Foundation;

    2. 201501-201812   Chinese National Natural Science Foundation: Mechanism Investigation of the establishment of aberrant methylation at tumor suppressor gene promoters via DNMT1 and polII

    201701-202012   Chinese National Natural Science Foundation


    The applicant should be between 23-35 years old, healthy, has obtained bachelor degreeor master degree,with good marks (GPA>3.75), has working experience, has solid financial support to afford the study and living expenses in China,from Chinese Government Scholarship (CSC) or other Scholarship. 

    Requires students to have goodEnglish interactionability, and goodbiological statistics or bioinformatics background.

    This major can accepttwo students for master degree and two for PhD degree.